The National Gene Vector Biorepository (NGVB)

We are an NHLBI/NIH funded resource for investigators conducting clinical gene therapy research.

Our databases and educational resources are open to everyone. Other services may be limited to academic institutions, non-profit organizations, and companies that qualify for NIH small-business grants.

Archiving

The NGVB can provide GLP archiving of samples generated for Pharm/Tox studies. Storage of GMP material and clinical samples is also available. The services are provided free for eligible institutions.

Testing

The NGVB testing include (1) PCR based assays for vector copy number and replication competent retrovirus; (2) biologic assays for replication competent viruses; (3) PERT.

Pharm/Tox Database

The NGVB provides detailed summaries of over 50 gene therapy Pharmacology and Toxicology studies. We can facilitate letters of cross-reference so investigators can avoid repeating studies already on file with the FDA.

Reagent Repository

The NGVB has a repository of over 80 reagents, including AAV and lentiviral vector plasmids, certified cell lines, and retroviral packaging cell lines.

Insertion Site Analysis

PCR, next-generation sequencing, and bioinformatics analysis are available to eligible investigators.

Resources

This website provides links to funding agencies, NIH resources, gene therapy societies, and important FDA documents.

What's New at the NGVB

Two Items of Note!

1) Please check out the review of NGVB activities published in Human Gene Therapy

The National Gene Vector Biorepository. Eleven Years of Providing Resources to the Gene Therapy Community. Human Gene Therapy: 31, 145-150. https://doi.org/10.1089/hum.2019.317

2) NGVB as two new services (Contact us to see if you are eligible):

a) Vector Copy Number
b) Insertion Site Analysis including next-generation sequencing and bioinformatics