The National Gene Vector Biorepository (NGVB)

We are an NHLBI/NIH funded resource for investigators conducting clinical gene therapy research.

Our databases and educational resources are open to everyone. Other services may be limited to academic institutions, non-profit organizations, and companies that qualify for NIH small-business grants.

Archiving

The NGVB can provide GLP archiving of samples generated for Pharm/Tox studies. Storage of GMP material and clinical samples is also available. The services are provided free for eligible institutions.

Testing

The FDA requires testing of vector products, gene modified cells, as well as post-trial monitoring of patients treated with gene therapy. The NGVB provides an array of tests to help investigators meet these unique FDA requirements.

Pharm/Tox Database

The NGVB provides detailed summaries of over 50 gene therapy Pharmacology and Toxicology studies. We can facilitate letters of cross-reference so investigators can avoid repeating studies already on file with the FDA.

Reagent Repository

The NGVB has a repository of over 80 reagents, including AAV and lentiviral vector plasmids, certified cell lines, and retroviral packaging cell lines.

Seqmap 3

SeqMap 3 is a publically available bioinformatics tool suitable for identifying vector insertion sites from Next-Gen Sequencing of LAM-PCR and nrLAM-PCR products.

Educational Resources

This website provides links to funding agencies, NIH resources, gene therapy societies, and important FDA documents.

What's New at the NGVB

On December 18, 2018, the National Heart, Lung, and Blood Institute has refunded the NGVB grants a 5 year contract to continue and further expand important resources for gene therapy investigators.

Look for upcoming announcements on improved services!